`t-cells Are Mhc Restricted`. Discuss This Statement.

/Naive_T_cell \o Naive T cell napve responses , although B-cells and macrophages cornerstone be important armored personnel carriersSince antibody can non enter infect cells and phagocytes cannot detect that they atomic number 18 infected , cytotoxic T-cells must be activated to hear and dash off the infected cells . To be activated by endogenous antigen , CD8 T-cells occasion their T-cell receptor TCR to confiscate endogenous antigen peptides presented on membrane variance I MHC proteins of target or infected cells . T-cell precursors however hail to the thymus from the Bone MarrowT-cells are major Histocompatibility Complex MHC-restricted in their ability to see antigen , they alone admit it presented by syngeneic or self MHC on APC . CD4 T-cells bind exogenous antigen on furcate II MHC of professional APC , macro phages and B-cells . T-cell receptor TCR binds two peptide plus Class II MHC domains . CD8 T-cells earn antigen on Class I MHC of cells infected with endogenous pathogens . different B-cells T-cells do not recognize antigens directly . They see antigen as peptides altogether in association with host surface major Histocomptability MHC soupcons .

Since MHC molecules can only bind peptide molecules of 7-15 amino acids long , T-cells only recognize their particularised antigen in the form of small peptides . The antigen presenting cells such(prenominal) as macrophages and B-cells dumbfound up antigen and partially degrade it into peptides which and then occupy the antigen-presenting wrinkle in MHC-I and MHC-II molecules (Dec! ker Janet M , 2006T-cells cannot recognize alone intact antigens or non-proteinaceous antigens such as carbohydrates . The two chassises of MHC molecule MHC class I , which primarily present intracellular antigens and MHC class II , which primarily present extra cellular antigens . CD8 T-cells can only recognize antigen in association with MHC I . The role of the CD8 molecule would be to bind MHC I and thus uphold this association Without fundamental interaction with CD8 , T-cells will not be activated...If you want to get a full essay, order it on our website: OrderEssay.net

If you want to get a full information about our service, visit our page: write my essay